MOTS-c

Description

For Research Use Only. This product is supplied exclusively for laboratory research and is not intended for human or veterinary use.

MOTS-c Research Peptide

MOTS-c (mitochondrial ORF of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide. ZENTRA supplies it as high-purity lyophilised research material in 10mg and 40mg formats for controlled laboratory and analytical applications.

Published research identifies the human MOTS-c sequence as MRWQEMGYIFYPRKLR. The peptide is encoded within a short open reading frame in mitochondrial 12S rRNA and has been investigated in experimental models of cellular bioenergetics, metabolic signalling, stress adaptation and skeletal-muscle homeostasis.

Technical Specifications

Independent Batch Testing

Every current ZENTRA MOTS-c batch is independently tested and records an HPLC purity result above 99%. The batch number on the product label can be checked against the corresponding third-party report in our Batch Verification and COA Centre. Researchers should consult the individual report for the exact analytical methods, purity result and testing date for their supplied batch.

MOTS-c Research Context

The original 2015 research identified MOTS-c as a mitochondrial-derived peptide and investigated its effects on cellular glucose metabolism, AMPK-related signalling and metabolic homeostasis in cultured cells and mouse models. A 2018 cell study found that MOTS-c could move to the nucleus during metabolic stress and influence adaptive nuclear gene expression.

A 2021 study reported that acute exercise increased endogenous MOTS-c expression in human skeletal muscle and circulation in a small experimental cohort. The same paper examined age-dependent physical capacity and skeletal-muscle homeostasis in mice. These findings are useful research signals, but they do not establish a therapeutic effect, safety profile or approved use in humans.

The evidence base remains predominantly preclinical, with limited human observational and experimental data. ZENTRA supplies MOTS-c solely as a research compound and does not provide medical, therapeutic or dosing guidance.

Storage and Handling

For long-term storage, keep unopened lyophilised material at approximately -20°C. For short-term laboratory storage, maintain at 2-8°C. Protect the vial from light, moisture and repeated temperature changes. Use appropriate laboratory handling procedures and consult your institutional protocol before preparing research solutions.

MOTS-c Research FAQs

What is MOTS-c?

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. It is studied as a signalling molecule involved in cellular energy and stress-response pathways.

What is the MOTS-c sequence and molecular weight?

The published human sequence is MRWQEMGYIFYPRKLR. Its molecular weight is approximately 2174.6 g/mol.

Which MOTS-c sizes are available?

This product is available as 10mg and 40mg of lyophilised research material. Select the required format before adding it to the basket.

How is MOTS-c purity verified?

Every current batch is tested by an independent laboratory using HPLC and records a purity result above 99%. The matching report can be found using the batch number printed on the product label.

What research areas have examined MOTS-c?

Published studies have investigated mitochondrial signalling, cellular bioenergetics, AMPK-related pathways, metabolic-stress responses and skeletal-muscle homeostasis. Most evidence comes from cell and animal models; human evidence remains limited.

Is this product intended for human or veterinary use?

No. ZENTRA MOTS-c is supplied strictly for laboratory research and analytical purposes. It is not intended for human consumption, veterinary use, diagnosis or treatment.

Selected Primary Research

1. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
2. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress.
3. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.

Research Resources

• MOTS-c Batch Verification and COAs
• Research Peptide Storage Guide
• Lyophilised Peptide Reconstitution Guide
• What Are Research Peptides?
• Browse All Research Peptides

For research use only. Not for human or veterinary use.